| 2010 Tampa Bay Buccaneers Results (10-6) |
| Date | Opponent | Site | Result | Attn |
| Sun Sep 12 | Cleveland | Tampa | Won 17-14 | 47,211 |
| Sun Sep 19 | Carolina | Charlotte | Won 20-7 | 72,579 |
| Sun Sep 26 | Pittsburgh | Tampa | Lost 38-13 | 61,036 |
| Sun Oct 10 | Cincinnati | Cincinnati | Won 24-21 | 63,888 |
| Sun Oct 17 | New Orleans | Tampa | Lost 31-6 | 51,759 |
| Sun Oct 24 | St. Louis | Tampa | Won 18-17 | 42,020 |
| Sun Oct 31 | Arizona | Glendale | Won 38-35 | 61,857 |
| Sun Nov 7 | Atlanta | Atlanta | Lost 27-21 | 67,266 |
| Sun Nov 14 | Carolina | Tampa | Won 31-16 | 44,264 |
| Sun Nov 21 | San Francisco | San Francisco | Won 21-0 | 69,732 |
| Sun Nov 28 | Baltimore | Baltimore | Lost 17-10 | 70,989 |
| Sun Dec 5 | Atlanta | Tampa | Lost 28-24 | 53,955 |
| Mon Dec 12 | Washington | Landover, MD | Won 17-16 | 66,124 |
| Sun Dec 19 | Detroit | Tampa | Lost 23-20 | 47,692 |
| Sun Dec 26 | Seattle | Tampa | Won 38-15 | 46,576 |
| Sun Jan 2 | New Orleans | New Orleans | Won 23-13 | 70,068 |
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